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Aminopeptidase N(APN) is an important drug target and biomarker for various tumors.The current work characterizes a novel APN-targeted fluorescent probe(Bes-Green,2) that manifests comparable inhibitory activity with Bestatin.This probe has capacity of tightly binding to the APN for imaging endogenous APN in living human ovarian clear cell carcinoma cells(ES-2) and has potential application in biological study of cellular APN.
A currentopeptidase N (APN) is an important drug target and biomarker for various tumors. Current work characterizes a novel APN-targeted fluorescent probe (Bes-Green, 2) that manifests comparable inhibitory activity with Bestatin. This probe has capacity of tightly binding to the APN for imaging endogenous APN in living human ovarian clear cell carcinoma cells (ES-2) and has potential application in biological study of cellular APN.