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目的:研究三黄益气液在不同时间给药对代谢综合征肥胖人群的疗效差别。方法:以20名健康志愿者为对照,将120名代谢综合征患者随机分为6组,分别于每天0、4、8、12、16、20点钟给予三黄益气液治疗12周,观察治疗前后患者心血管危险因素的变化,确定三黄益气液的最佳给药时间。结果:与其它各组相比,8点服药组人群除空腹血糖、甘油三酯无显著差异外,腰围、体质量指数、腰臀围比值、胰岛素抵抗指数、血清C反应蛋白、游离脂肪酸水平明显改善,差异均有显著性。结论:三黄益气液于早上8点服用,在降低代谢综合征人群肥胖、胰岛素抵抗程度,改善炎症状态,减轻致心血管病的危险性方面显著优于其它时间点给药。
OBJECTIVE: To study the therapeutic effect of Sanhuang Yiqiye on obesity in patients with metabolic syndrome at different times. Methods: A total of 120 patients with metabolic syndrome were randomly divided into six groups according to 20 healthy volunteers. Sanhuang Yiqi liquid was given for 12 weeks at 0,4,8,12,16 and 20 o’clock, Changes in cardiovascular risk factors before and after treatment were observed to determine the best administration time of Sanhuang Yiqiye. Results: In addition to fasting blood glucose and triglycerides, the waist circumference, body mass index, waist-hip ratio, insulin resistance index, serum C-reactive protein, and free fatty acid levels were significantly higher in the 8-point medication group compared with the other groups Improve, the difference is significant. Conclusion: Sanhuang Yiqi liquid was taken at 8:00 in the morning, which was significantly better than other time points in reducing the obesity, insulin resistance, improving the inflammatory state and reducing the risk of causing cardiovascular disease in the metabolic syndrome population.