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本文在动物实验的基础上,前瞻性地研究锂离子导入对甲状腺功能的影响。动物实验表明,导入组甲状腺锂浓度(1.11±0.35μg/g)明显高于血清锂浓度(0.34±0.26μg/g),差异显著(P<0.01)。锂离子导入二周后,14例甲亢病人 FreeT_4、FreeT_3明显降低(P<0.05)、其平均下降率 FreeT_4为62.1%,FreeT_3为45.1%;~(131)I 对摄率无影响(P>0.05);~(131)I 有效半表期平均延长2.1天(约0.6倍),并且病人临床症状改善早,全组14例均无锂的毒副作用出现。此时如合用小剂量~(131)I,则可在症状改善的同时,获得较好放射治疗效果。
In this paper, based on animal experiments, a prospective study of lithium ion on thyroid function. Animal experiments showed that the concentration of thyroid lithium (1.11 ± 0.35μg / g) was significantly higher than that of serum lithium (0.34 ± 0.26μg / g), the difference was significant (P <0.01). FreeT_4 and FreeT_3 in 14 patients with hyperthyroidism were significantly lower (P <0.05) after 2 weeks of lithium ion implantation. The average descent rate of FreeT_4 was 62.1% and FreeT_3 was 45.1% ). The effective half-period of ~ (131) I was extended by 2.1 days (about 0.6 times) on average, and the clinical symptoms of the patients were improved as early as possible. No toxic side effects occurred in all 14 patients. At this time if combined with low-dose ~ (131) I, the symptoms can be improved at the same time, get better radiotherapy.