应用间接免疫荧光法，观察孔源性视网膜脱离合并增生性玻璃体视网膜病变（ＰＶＲ）、外伤性网脱合并ＰＶＲ和增生型糖尿病视网膜病变（ＰＤＲ）各４例病例的视网膜前膜中单核细胞趋化蛋白－１（ＭＣＰ－１）的表达。结果表明：３组病例视网膜前膜中均见有ＭＣＰ－１阳性细胞，其细胞大小、形态无明显差别。提示：ＭＣＰ－１存在于ＰＶＲ和ＰＤＲ的视网膜前膜中，并参与这两种病变的形成，表明ＰＶＲ和ＰＤＲ的发病机制与趋化细胞因子及局部免疫反应有一定的关系。 Indirect immunofluorescence was used to observe the mononuclear cell proliferation in the retinal pre-membrane of 4 cases of rhegmatogenous retinal detachment complicated with proliferative vitreoretinopathy (PVR), traumatic nephrectomy and PVR and proliferative diabetic retinopathy (PDR) Protein-1 (MCP-1) expression. The results showed that MCP-1 positive cells were found in all the three groups of pre-retinal membranes, with no significant differences in cell size and morphology. Tip: MCP-1 is present in the pre-retinal membrane of PVR and PDR and is involved in the formation of these two pathologies, indicating that PVR and PDR have a relationship with chemotactic cytokines and local immune responses.