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抑癌基因(adenom atous polyposis coli,APC)基因是近年来肿瘤分子生物学研究的热点之一,APC蛋白是W nt信号通路β-caten in降解复合体的重要组分,在wnt信号通路异常或活化导致口腔鳞状细胞癌的发生中,发挥重要的作用。APC的突变或缺失会导致β-caten ine蛋白在胞浆及胞核内异
The gene of tumor suppressor gene (APC) is one of the hot topics in tumor molecular biology in recent years. APC protein is an important component of Wnt signaling pathway β-caten in degradation complex, Activated lead to the occurrence of oral squamous cell carcinoma, play an important role. Mutations or deletions of APC result in different cytoplasmic and nuclear β-catenine proteins