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目的：研究ＴＧＦ－β１及其受体ＴＧＦ－βＲⅠ在烧伤后增生性瘢痕不同时期的表达．方法：免疫组化ＡＢＣ法．结果：在正常真皮成纤维细胞中ＴＧＦ－β１及ＴＧＦ－βＲⅠ未检测到阳性表达；增生期的增生性瘢痕的真皮中ＴＧＦ－β１及ＴＧＦ－βＲⅠ在相同的成纤维细胞亚群中高表达，而萎缩期的增生性瘢痕中两者表达均为阴性．结论：提示增生性瘢痕的形成与成纤维细胞对ＴＧＦ－β１的反应性增高有关，同时也与伤口愈合高表达ＴＧＦ－βＲⅠ的成纤维细胞亚群不能及时发生凋亡有关．
Objective: To investigate the expression of TGF-β1 and its receptor TGF-βRⅠ in different stages of hypertrophic scar after burn injury. Methods: Immunohistochemical ABC method. RESULTS: No positive expression of TGF-β1 and TGF-βRⅠ was found in normal dermal fibroblasts. TGF-β1 and TGF-βRⅠ in the proliferative dermis of hypertrophic scar were highly expressed in the same fibroblast subfamily Shrinkage of hypertrophic scars in both expression were negative. Conclusion: It is suggested that the formation of hypertrophic scars is related to the increased reactivity of fibroblasts to TGF-β1 and the apoptosis of TGF-βRI-deficient fibroblasts in wound healing.