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细胞周期素D(cyclin D)家族的3位成员,是最先启动细胞周期G1/S检测点调控的周期蛋白因子。研究发现,cyclin D家族的作用机制与众多癌基因、抑癌基因信号传导途径均存在着密切联系。本文就目前已知的细胞G1/S检测调控点与cyclin D相关信号传导途径的进展作一综述。
The 3 member of the cyclin D family is the first cyclin factor that initiates the regulation of the G1 / S cell cycle. The study found that, cyclin D family mechanism and many oncogenes, tumor suppressor gene signaling pathways are closely linked. This review summarizes the progress of G1 / S detection and cyclin D signaling pathways.