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目的 探讨诱导型一氧化氮合酶 (iNOS)在口腔癌前病变、口腔鳞癌发展过程中的表达情况及其作用。方法 采用免疫组化SABC法检测 10例正常口腔黏膜、8例上皮单纯增生、2 0例上皮异常增生和 3 2例鳞状细胞癌组织中iNOS的表达。结果 正常口腔黏膜iNOS阴性表达 ;上皮异常增生组和鳞癌组中iNOS的表达较上皮单纯增生组均显著增加 (P <0 .0 5 ) ;随着上皮异常增生程度的加重 ,iNOS的标记指数逐级显著上升 (P <0 .0 5 ) ;上皮异常增生组与鳞癌组之间以及鳞癌的各病理分级之间iNOS的表达均无显著性差异 (P >0 .0 5 )。结论 iNOS的表达可能参与了口腔鳞癌的衍进过程
Objective To investigate the expression of inducible nitric oxide synthase (iNOS) in oral precancerous lesions and oral squamous cell carcinoma and its role. Methods Immunohistochemical SABC method was used to detect the expression of iNOS in 10 cases of normal oral mucosa, 8 cases of epithelial hyperplasia, 20 cases of epithelial dysplasia and 32 cases of squamous cell carcinoma. Results The expression of iNOS in normal oral mucosa was negative. The expression of iNOS in epithelial dysplasia group and squamous cell carcinoma group was significantly higher than that in epithelial simple hyperplasia group (P <0.05). With the increase of epithelial dysplasia, the iNOS labeling index There was no significant difference in iNOS expression between epithelial dysplasia group and squamous cell carcinoma group and between squamous cell carcinoma group (P> 0.05). Conclusion The expression of iNOS may be involved in the process of oral squamous cell carcinoma