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目的评价1,6-二磷酸果糖治疗慢性心衰的临床疗效和对血液流变学的影响。方法治疗组在基础治疗的基础上加用1,6-二磷酸果糖静滴。对照组只采用基础治疗。结果治疗组总有效率(94.3%)明显高于对照组(70%)(P<0.05);与对照组比较,FDP组全血黏度高切、中切、低切的改变均有统计学意义(P<0.01);治疗组治疗后全血黏度、血浆黏度、红细胞压积、血小板聚集率等均有明显改善(P<0.01);纤维蛋白原(FBG)、血小板(PC)降低(P<0.01)。结论采用1,6-二磷酸果糖与抗心力衰竭常规方法联合应用,能有效改善心脏微循环和血流动力学,增强心功能,提高治愈率、减少病死率。
Objective To evaluate the clinical efficacy of fructose-1,6-diphosphate in the treatment of chronic heart failure and its effect on hemorrheology. Methods The treatment group was treated with fructose-1,6-diphosphate intravenously on the basis of basic treatment. The control group only used basic treatment. Results The total effective rate (94.3%) in the treatment group was significantly higher than that in the control group (70%) (P <0.05). Compared with the control group, the change of whole blood viscosity in the FDP group was statistically significant (P <0.01). After treatment, the whole blood viscosity, plasma viscosity, hematocrit and platelet aggregation rate of the treatment group were significantly improved (P <0.01); the levels of fibrinogen (FBG) and platelet (PC) 0.01). Conclusions The combination of fructose - 1, 6 - diphosphate and conventional method of anti - heart failure can effectively improve cardiac microcirculation and hemodynamics, enhance cardiac function, improve cure rate and reduce mortality.