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肉眼及光镜下观察了毛冬青甲素对肾血管性高血压大鼠脑内血肿的影响。电镜下观察了毛冬青甲素对肾血管性高血压大鼠脑血肿病理模型术后脑微血管超微结构的影响。发现毛冬青甲素治疗组血肿吸收快,毛细血管增生活跃,组织修复好。治疗后其脑微血管内皮光滑,内皮细胞核及线粒体肿胀减轻,管腔无狭窄,内无血栓形成及血小板聚集。对照组治疗后毛细血管增生较少,组织修复不理想。其脑微血管内皮毛糙,微绒毛增多,内皮细胞核及线粒体肿胀,管腔明显受压变窄,并有微血栓形成及血小板聚集,管用水肿,提示毛冬青甲素治疗高血压性脑出血是可行的、有效的,并说明毛冬青甲素确有疏通血管,改善微循环,增加脑血流量,促进血肿吸收及脑组织修复的作用。
The effects of scopolamine (A) on the cerebral hematoma in renovascular hypertensive rats were observed under naked and light microscope. Under electron microscopy, the effect of Maodongqingsu on the ultrastructure of cerebral microvasculature after pathological model of cerebral hematoma in renovascular hypertensive rats was observed. It was found that the heparin treatment group had rapid absorption of hematoma, active capillary hyperplasia, and good tissue repair. After the treatment, the cerebral microvascular endothelium was smooth, the nuclear and mitochondrial swelling of the endothelial cells were relieved, the lumen was not narrow, and there was no thrombus formation and platelet aggregation. The control group had less capillary hyperplasia after treatment and the tissue repair was not ideal. The brain microvascular endothelial rough, microvilli increased, endothelial cell nuclei and mitochondria swelling, the lumen was significantly pressure narrowing, and microthrombosis and platelet aggregation, tube edema, suggesting that the treatment of hyperuric intracerebral hemorrhage A , effective, and that Maodongqingsu A really clear the blood vessels, improve microcirculation, increase cerebral blood flow, promote hematoma absorption and brain tissue repair.