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目的探讨日达仙(胸腺肽α1)对肾病综合征患儿细胞、体液免疫的影响。方法对20例肾病综合征患儿,在常规治疗的同时加用日达仙1.6 mg,1次/日,皮下注射,连用5天为1疗程,在治疗前后检测外周血T淋巴细胞亚群、体液免疫及尿蛋白等指标并进行相关统计分析。结果治疗前T细胞亚群呈现CD8+增高、CD4+降低,治疗后CD8+降低(P<0.01)、CD4+升高(P<0.01);治疗前体液免疫中IgG明显降低,IgE明显增高,治疗后IgG升高(P<0.01)、IgE降低(P>0.05)。结论日达仙可调节肾病综合征患儿外周血细胞免疫、体液免疫水平,纠正免疫功能紊乱,对治疗起着积极的作用。
Objective To investigate the effect of Zadaxin (Thymosin α1) on cellular and humoral immunity in children with nephrotic syndrome. Methods Twenty children with nephrotic syndrome were treated with daily dose of 1.6 mg daily, subcutaneously and once daily for 5 days for one course of treatment. T lymphocyte subsets in peripheral blood were detected before and after treatment. Humoral immunity and urinary protein and other indicators and related statistical analysis. Results Pretreatment T lymphocyte subsets showed increased CD8 +, CD4 +, decreased CD8 + (P <0.01) and increased CD4 + (P <0.01) after treatment. Before treatment, IgG in serum decreased significantly and IgE increased significantly. High (P <0.01), IgE decreased (P> 0.05). Conclusion Zadaxin can regulate peripheral blood cell immunity and humoral immunity in children with nephrotic syndrome and correct immune dysfunction, which plays a positive role in the treatment.