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内毒素(Endotoxin)是革兰氏阴性菌感染的重要致病因子,也是诱发炎症反应的主要致病成分,其活性成分是脂多糖(LPS)。内毒素的致病机理错综复杂,迄今尚未完全了解和阐明,对其治疗也无满意的药物和措施,但随着对内毒素的结构组成、生物学活性与致病机制等方面的认识不断深入,近年来对内毒素及其拮抗药物的研究也日益增多。就细菌内毒素及其拮抗药物的研究新进展作一简要综述。
Endotoxin is an important virulence factor of Gram-negative bacteria infection. It is also the main pathogenic component of inflammatory reaction. Its active ingredient is lipopolysaccharide (LPS). The pathogenesis of endotoxin is complex and has not yet been fully understood and elucidated. There are no satisfactory drugs and measures for its treatment. However, with the understanding of the structural composition, biological activity and pathogenic mechanism of endotoxin, In recent years, the research on endotoxin and its antagonistic drugs is also increasing. A brief review on the recent advances in bacterial endotoxin and its antagonistic drugs.