糖精作为食糖代用品、食品添加剂已有80多年,人们一直认为是无毒的化学品。近年来,国外对糖精是否安全进行了激烈的争议,但迄今尚无定论。据报道在加拿大的大鼠实验中,用糖精喂饲100只大鼠,剂量为饲料的5%(约2,500毫克/公斤体重),有3只发生膀胱癌,其子代(在子宫内即接触 Saccharin as a sugar substitute, food additives for over 80 years, people have always considered non-toxic chemicals. In recent years, foreign countries on the safety of saccharin has been heated controversy, but so far no conclusion. It has been reported that in rats in Canada, 100 rats were fed saccharin at a dose of 5% of the feed (about 2,500 mg / kg body weight), three developed bladder cancer, and their offspring (exposed in the uterus