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长链脂肪酸受体GPR120属于G蛋白偶联受体GPCRs中的一员,也称为3FAR1或ω3脂肪受体1,因其是游离长链不饱和脂肪酸受体,在多种生理生化反应中都有着至关重要的作用。它不仅可以调节胃肠道激素分泌、脂肪细胞发育和分化,促进细胞增殖,介导抗炎症作用,还与肥胖和糖尿病等代谢疾病的发生密切相关。作为当下研究热点,其激动剂的研究也是非常活跃的领域。文章主要就近来GPR120受体的研究现状及其有关的新药研发做一综述。
The long-chain fatty acid receptor GPR120 belongs to one of the G-protein coupled receptor GPCRs, also known as 3FAR1 or ω3 fat receptor 1, which is a free long chain unsaturated fatty acid receptor that is involved in various physiological and biochemical reactions Has a vital role. It can not only regulate gastrointestinal hormone secretion, adipocyte development and differentiation, promote cell proliferation, mediate anti-inflammatory effect, but also with obesity and diabetes and other metabolic diseases are closely related. As the current research hotspot, its agonist research is also very active field. The article mainly reviews the recent research status of GPR120 receptor and its related research and development of new drugs.