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目的探讨影响阴茎鳞状细胞癌预后的可能因素。方法回顾性分析102例阴茎恶性肿瘤患者的临床资料,分析影响阴茎鳞状细胞癌预后的可能因素。结果 63例阴茎鳞状细胞癌患者获得随访1-177个月。5年总生存率、无瘤生存率和肿瘤特异性生存率分别为71.8%、64.5%和76.9%。单因素分析显示,肿瘤分期、组织学级别、区域淋巴结状态及淋巴外扩散均与术后生存率密切相关(P<0.05或P<0.01)。多因素分析表明,肿瘤低分化和区域淋巴结阳性是预后的独立影响因素(P<0.01和P<0.05)。结论区域淋巴结阳性及肿瘤组织学高级别显著降低患者的术后生存率。
Objective To explore the possible factors that affect the prognosis of penis squamous cell carcinoma. Methods The clinical data of 102 patients with penile malignant tumor were retrospectively analyzed, and the possible factors affecting the prognosis of penile squamous cell carcinoma were analyzed. Results 63 cases of penile squamous cell carcinoma were followed up for 1-177 months. 5-year overall survival, tumor-free survival and tumor-specific survival were 71.8%, 64.5% and 76.9%. Univariate analysis showed that tumor stage, histological grade, regional lymph node status and lymphatic spread were closely related to postoperative survival (P <0.05 or P <0.01). Multivariate analysis showed that poorly differentiated tumor and regional lymph node positive were independent prognostic factors (P <0.01 and P <0.05). Conclusions The regional lymph node positive and high grade of tumor histology significantly reduce the postoperative survival rate of patients.