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目的:研究黄芪精对实验动物胃粘膜的保护作用。方法:测定胃粘膜损伤指数、胃液量、胃液酸度和胃蛋白酶活性。结果:黄芪精(1.25～5.0g·kg-1~(-1),ig)可剂量依赖性抑制95％乙醇(小鼠)和幽门结扎(大鼠)诱发的实验性胃粘膜损伤,但对大鼠胃液量、胃液酸度和胃蛋白酶活性无明显影响。黄芪精可协同西味替丁对胃粘膜的保护作用。结论;黄芪精与西咪替丁联用可治疗消化性溃疡。
Objective: To study the protective effect of astragaloside on gastric mucosa in experimental animals. Methods: Gastric mucosal injury index, gastric juice volume, gastric juice acidity and pepsin activity were measured. RESULTS: Astragaloside (1.25-5.0 g·kg-1~(-1), ig) dose-dependently inhibited experimental gastric mucosal injury induced by 95% ethanol (mice) and pyloric ligation (rats), but Rat gastric juice volume, gastric acidity and pepsin activity had no significant effect. Astragalus can synergize the protective effect of sethoxystilbate on gastric mucosa. Conclusion: Astragaloside combined with cimetidine can treat peptic ulcer.