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目的:了解节细胞性副神经节瘤的临床病理特点、诊断和鉴别诊断。方法:对1例膀胱节细胞性副神经节瘤进行光镜和免疫组织化学观察,并结合文献进行分析。结果:肿瘤组织由3种细胞组成,即上皮样细胞、梭形神经鞘细胞样细胞和成熟的神经节细胞。免疫组织化学标记上皮样细胞表达嗜铬素、突触素、神经元特异性烯醇化酶;梭形细胞表达一抗波形蛋白、神经纤维细丝蛋白、S-100蛋白;神经节细胞表达胶质纤维酸性蛋白、神经元特异性烯醇化酶、神经纤维细丝蛋白。结论:节细胞性副神经节瘤非常罕见,好发于十二指肠,也可发生于膀胱,大多为良性肿瘤,根据其病理形态学特点结合免疫表型可做出正确诊断。
Objective: To understand the clinicopathological features, diagnosis and differential diagnosis of gangliocytic paraganglioma. Methods: One case of ganglion cell paraganglioma was observed by light microscopy and immunohistochemistry combined with the literature. Results: The tumor tissue consisted of three kinds of cells, namely epithelial cells, spindle-shaped neuroendocell-like cells and mature ganglion cells. Immunohistochemical labeling of epithelial-like cells expressed chromogranin, synaptophysin, and neuron-specific enolase; spindle-shaped cells expressed an anti-vimentin, nerve fiber filament protein, S-100 protein; ganglion cells expressed glial Fibrillary acidic protein, neuron-specific enolase, nerve fiber filament protein. Conclusion: Paracellular ganglion cells are rare and occur in the duodenum. They may also occur in the bladder and are mostly benign tumors. Correct diagnosis can be made according to their pathomorphological features and immunophenotype.