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微粒体甘油三酯转移蛋白(MTP)是一种独特的脂质转移蛋白,在富含载脂蛋白(Apo)B的脂蛋白合成和分泌中起重要作用。其主要存在于内质网中,在肠上皮细胞的刷状缘黏膜囊泡中也分离得到[1]。MTP通过穿梭机制催化甘油三酯(TG)、胆固醇酯和磷脂酰胆碱在磷脂表面的转运。它的表达受饮食
Microsomal triglyceride transfer protein (MTP) is a unique lipid transfer protein that plays an important role in the synthesis and secretion of lipoproteins rich in apolipoprotein (Apo) B. It is mainly present in the endoplasmic reticulum and is also isolated in brush border mucosal vesicles of the intestinal epithelium [1]. MTP catalyzes the transport of triglyceride (TG), cholesteryl ester and phosphatidylcholine on the phospholipid surface through a shuttle mechanism. Its expression is affected by diet