【摘 要】
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Background : The Omicron (B.1.1.529) SARS- COV- 2 variant has raised serious con-cerns because of its unprecedented rapid rate of spreading and the fact that there are 36 mutations in the spike protein. Since the vaccine-i nduced neutralizing antibody tar
【机 构】
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Beijing Key Laboratory for Animal Models of Emerging and Reemerging Infectious Diseases,NHC Key Labo
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Background : The Omicron (B.1.1.529) SARS- COV- 2 variant has raised serious con-cerns because of its unprecedented rapid rate of spreading and the fact that there are 36 mutations in the spike protein. Since the vaccine-i nduced neutralizing antibody targets are the spike protein, this may lead to the possibility of vaccine-i nduced hu-moral immunity escape.Methods : We measured the neutralizing activity in vitro for Omicron and compared this with wild type (WH- 09) and Delta variants in human and monkey sera from dif-ferent types of immunity. The monkey sera samples were collected at 1 and 3 months post three- dose inactivated (PiCoVacc) and recombinant protein (ZF2001) vaccination. Human sera were collected from 1 month post three- dose inactivated vaccination. Results : In inactivated vaccine sera, at 1/3 months post three- dose, geometric mean titers (GMTs) of neutralization antibody (NAb) against the Omicron variant were 4.9/5.2- fold lower than those of the wild type. In recombinant protein vaccine sera, GMTs of NAb against Omicron were 15.7/8.9- fold lower than those of the wild type. In human sera, at 1 month post three- dose inactivated vaccination, GMTs of NAb against Omicron were 3.1- fold lower than those of the wild type. Conclusion : This study demonstrated that despite a reduction in neutralization titers, cross- neutralizing activity against Omicron and Delta variants was still observed after three doses of inactivated and recombinant protein vaccination.
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