论文部分内容阅读
目的:探讨氟康唑胶囊联合知柏地黄丸对滴虫性阴道炎患者血清白细胞介素-10(IL-10)、肿瘤坏死因子-α(TNF-α)的影响及临床疗效。方法:收集我院就诊的78例滴虫性阴道炎患者,随机分为实验组和对照组,各39例。对照组患者给予氟康唑胶囊治疗,实验组在对照组基础上给予知柏地黄丸治疗。观察并比较两组患者治疗前后IL-10、TNF-α、阴道健康评分及临床疗效。结果:与治疗前相比,两组患者治疗后血清IL-10、TNF-α水平均显著下降,阴道健康评分均明显升高,差异具均有统计学意义(P<0.05);与对照组相比,实验组患者治疗后血清IL-10、TNF-α水平较低,阴道健康评分和临床治疗总有效率均较高,差异均具有统计学意义(P<0.05)。结论:氟康唑胶囊联合知柏地黄丸能够有效提高滴虫性阴道炎患者的临床疗效,可能与其显著降低血清IL-10、TNF-α水平有关。
Objective: To investigate the effects of fluconazole capsule combined with Zhibai Dihuang Wan on serum interleukin-10 (IL-10) and tumor necrosis factor-α (TNF-α) in patients with trichomonas vaginitis and its clinical efficacy. Methods: Totally 78 cases of trichomonas vaginitis were collected in our hospital and randomly divided into experimental group and control group, with 39 cases each. Patients in the control group were treated with fluconazole capsules. The experimental group was given Zhibai Dihuang Wan on the basis of the control group. The levels of IL-10, TNF-α, vaginal health before and after treatment and the clinical curative effect were observed and compared between the two groups. Results: Compared with those before treatment, the serum levels of IL-10 and TNF-α in both groups were significantly decreased and the vaginal health scores were significantly increased (all P <0.05). Compared with the control group Compared with the control group, the levels of serum IL-10 and TNF-α in the experimental group were lower, the scores of vaginal health and the total effective rate of clinical treatment were higher, the differences were statistically significant (P <0.05). Conclusion: Fluconazole capsule combined with Zhibai Dihuang Wan can effectively improve the clinical efficacy of trichomonas vaginitis patients may be related to its significantly lower serum levels of IL-10 and TNF-α.