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目的:观察干扰素、阿德福韦酯片治疗慢性乙型肝炎的近期疗效。方法:在同时期内对150例慢性乙型肝炎患者分别以干扰素α-2b、阿德福韦酯片、普通保肝药进行治疗,疗程均为6个月。结果:3组药物均有较好的降ALT、SB和改善白球蛋白比例的作用。同时具有一定的抑制HBV复制的作用。干扰素、阿德福韦酯片、普通保肝药3组的HBVDNA阴转率分别为54.6%、48.6%、12.1%;HBeAg的阴转率分别为57.7%、46.2%、15.2%;3组的HBeAg、HBVDNA、抗HBcIgM的3项全部阴转,分别为17.2%、26.3%、4.2%。结论:三组药物均能达到理想的抑制病毒的效果。
Objective: To observe the recent curative effect of interferon and adefovir dipivoxil on chronic hepatitis B. Methods: 150 patients with chronic hepatitis B were treated with interferon alfa-2b, adefovir dipivoxil tablets and ordinary hepatoprotective drugs during the same period, all of which were treated for 6 months. Results: All the three groups of drugs had better effects of decreasing ALT, SB and improving the ratio of white globulin. At the same time have a certain role in inhibiting HBV replication. The negative rate of HBVDNA in three groups of interferon, adefovir dipivoxil and common hepatoprotective drugs were 54.6%, 48.6% and 12.1% respectively; the negative conversion rates of HBeAg were 57.7%, 46.2% and 15.2% The three items of HBeAg, HBVDNA and anti-HBcIgM were all negative, with 17.2%, 26.3% and 4.2% respectively. Conclusion: The three groups of drugs can achieve the desired effect of inhibiting the virus.