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一般认为影响乳癌预后的因素是腋窝淋巴结受侵数目、肿瘤大小、雌激素受体、肿瘤病理学分级、停经状态等。本文的研究结果显示HER-2/neu表达状态与激素受体及自然杀伤(NK)细胞活性之间的相关性,以及HER-2/neu表达阳性与阴性的显著差异,改变了以前对HER-2/neu致癌基因表达的某些看法;并探讨了HER-2/neu过度表达影响免疫功能的机制;指出HER-2/neu表达是影响乳癌预后因素中一个新增加的独立的重要因素。 对109例可疑乳癌患者行乳房切除术,标本迅速用液氮冰冻。常规石蜡切片,进行形态学诊断,发现其中23例无恶性病变,86例为原发
It is generally believed that the factors affecting the prognosis of breast cancer are the number of invasion of axillary lymph nodes, tumor size, estrogen receptor, tumor pathological grade, and menopause status. The results of this study show that the HER-2/neu expression status correlates with hormone receptor and natural killer (NK) cell activity, as well as a significant difference between positive and negative HER-2/neu expression, which has changed previous to HER- Some views on the expression of 2/neu oncogenes; and explored the mechanism of HER-2/neu overexpression affecting immune function; pointed out that HER-2/neu expression is a new independent factor that influences the prognosis of breast cancer. Mastectomy was performed on 109 suspected breast cancer patients and the specimens were quickly frozen in liquid nitrogen. Conventional paraffin sections were used for morphological diagnosis and 23 cases were found to have no malignant lesions. 86 cases were primary