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We studied the effect of the simultaneous treatment withα-tocopherol(100 mg / kg;im) and nickel sulfate (20 mg/kg,ip) on nickel-induced changes in serum lipid profiles.Nickel-treated rats showed a significant increase in serum LDL cholesterol,total cholesterol,triglycerides,and a significant decrease in serum HDL cholesterol. Simultaneous administration ofα-tocopherol with nickel sulfate improved LDL-cholesterol and HDLcholesterol level when compared with rats receiving nickel sulfate alone.The results indicate thatα-tocopherol is beneficial in preventing nickel-induced lipid profile alterations.
We studied the effect of the simultaneous treatment with α-tocopherol (100 mg / kg; im) and nickel sulfate (20 mg / kg, ip) on nickel-induced changes in serum lipid profiles.Nickel-treated rats showed a significant increase in serum LDL cholesterol, total cholesterol, triglycerides, and a significant decrease in serum HDL cholesterol. Simultaneous administration of α-tocopherol with nickel sulfate improved LDL-cholesterol and HDL cholesterol levels when compared with rats receiving nickel sulfate alone. Results that α-tocopherol is beneficial in preventing nickel-induced lipid profile alterations.