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目的探讨染色体异常与不良生育史的关系。方法对682对不良生育史的夫妇的外周血T淋巴细胞进行细胞培养、G显带、核型分析。结果共检出异常核型36例,检出率5.28%。其中染色体平衡易位9例,占25%;罗氏易位8例,占22.2%;染色体臂间倒位4例,占11.1%;染色体多态性变异15例,占41.7%。结论染色体异常是导致不良生育史的重要原因之一,对高危人群应该行染色体检查,排除染色体畸变的可能。
Objective To explore the relationship between chromosomal abnormalities and poor reproductive history. Methods Peripheral blood T lymphocytes of 682 pairs of couples with unborn childbearing history were cultured, G - banding and karyotype analysis. Results A total of 36 cases of abnormal karyotype were detected, the detection rate was 5.28%. Among them, 9 cases were chromosomal equilibrium translocation, accounting for 25%; Roche translocation in 8 cases, accounting for 22.2%; chromosome inversion in arm 4 cases, accounting for 11.1%; chromosome polymorphism variation in 15 cases, accounting for 41.7%. Conclusion Chromosomal abnormalities are one of the most important causes of poor reproductive history. Chromosome examination should be performed in high-risk groups to eliminate chromosomal aberrations.