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目的:观察他汀类药物与血管紧张素转换酶抑制剂(ACEI)联用对急性冠脉综合征(ACS)患者的短期疗效及可能机制研究。方法:选取ACS患者60例,随机分为他汀治疗组和ACEI+他汀治疗组,在治疗4周后测定上述病例和对照组血清中C反应蛋白(CRP)和基质金属蛋白酶-9(MMP-9)的水平变化,观察两治疗组4周内主要终点事件发生情况,并进行统计学分析。结果:ACS组中血清CRP和MMP-9的水平明显高于对照组;ACEI+他汀治疗组在治疗4周后血清MMP-9的水平明显低于他汀治疗组,主要终点事件也有下降趋势。结论:他汀类药物与ACEI联用与单用他汀类药物比较,可通过更为显著降低MMP-9水平,达到减少冠状动脉粥样斑块基质成分的降解,稳定动脉粥样硬化斑块的作用。
Objective: To observe the short-term effects of statins combined with angiotensin converting enzyme inhibitor (ACEI) on patients with acute coronary syndrome (ACS) and its possible mechanism. Methods: Sixty ACS patients were randomly divided into statin group and ACEI + statin group. Serum levels of C-reactive protein (CRP) and matrix metalloproteinase-9 (MMP-9) The changes of the main endpoint events in the two treatment groups within 4 weeks were observed and statistically analyzed. Results: Serum levels of CRP and MMP-9 in ACS group were significantly higher than those in control group. The levels of serum MMP-9 in ACEI + statin group after 4 weeks of treatment were significantly lower than those in statin group, and the main endpoint events also showed a decreasing trend. Conclusions: Statins and ACEI combined with statin alone can reduce the matrix components of coronary atherosclerotic plaque and stabilize the atherosclerotic plaque through more significant reduction of MMP-9 .