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目的探讨两种黄体支持方法对多囊卵巢综合征不孕患者体外受精-胚胎移植(IVF-ET)术后妊娠结局的影响。方法对80例进行IVF-ET的多囊卵巢综合征不孕患者进行回顾性分析,按取卵后不同的黄体支持方法分组:A组(40例):取卵当日予以口服地屈孕酮,3次/d,10 mg/次,若为临床妊娠,连续用药至移植后60 d。B组(40例):取卵当日予以肌内注射黄体酮针剂,1次/d,40 mg/次,若为临床妊娠,连续用药至移植后60 d。结果A、B两组所获得的临床妊娠率、异位妊娠率、多胎妊娠率及早期流产率均无统计学差异(P>0.05)。结论对多囊卵巢综合征不孕患者在IVF-ET术后口服地屈孕酮进行黄体支持与肌内注射黄体酮针剂进行黄体支持所获得的妊娠结局是一致的,在临床上可以考虑将地屈孕酮替代黄体酮针剂进行黄体支持。
Objective To investigate the effect of two methods of luteal support on the outcome of pregnancy after in vitro fertilization-embryo transfer (IVF-ET) in patients with polycystic ovary syndrome. Methods 80 cases of infertility patients with polycystic ovary syndrome who underwent IVF-ET were retrospectively analyzed. According to the different luteal support methods after ovulation, group A (n = 40): on the day of ovulation, 3 times / d, 10 mg / time, if the clinical pregnancy, continuous medication to 60 days after transplantation. Group B (40 cases): the day of ovulation intramuscular injection of progesterone injection, 1 / d, 40 mg / time, if the clinical pregnancy, continuous medication to 60 days after transplantation. Results There was no significant difference in clinical pregnancy rate, ectopic pregnancy rate, multiple pregnancy rate and early miscarriage rate between groups A and B (P> 0.05). CONCLUSIONS: Pregnancy outcomes obtained with luteal support for oral contraceptive progesterone in women with polycystic ovary syndrome after IVF-ET surgery are consistent with those obtained with luteal-retinal intramuscular injection of progesterone injections. Clinically, Progesterone replacement progesterone injection for luteal support.