达罗地平(Darodipine)、尼卡地平和尼芬地平在10~(-6)M时在低浓度(5.5 mM)和高浓度(22 mM)的葡萄糖反应中对大鼠胰岛释放的胰岛素呈抑制作用。经12例哮喘志愿者的双盲、交叉、随机、安慰剂对照试验表明,达罗地平或者安慰剂经口服,第一天剂量为75 mg,第二、三天为150 mg。第二天服用达罗地平后,就基线值看,一秒钟用力最大呼出量显著增加,平均最大增长率为15±4%,而给安慰剂后为3±2%。本品抑制运动诱发的支气管痉挛。 19例心绞痛患者经双盲、交叉试验表 Darodipine, nicardipine and nifedipine inhibited insulin release from rat islets at 10 -6 M at low (5.5 mM) and high (22 mM) glucose reactions effect. A double-blind, crossover, randomized, placebo-controlled trial of 12 asthma volunteers showed that either daripodipine or placebo was administered orally at a dose of 75 mg on the first day and 150 mg on the second and third days. After taking daripodipine the next day, the maximal exhaled volume increased significantly for one second, with a mean maximum rate of 15 ± 4% on baseline and 3 ± 2% on placebo. This product inhibits exercise-induced bronchospasm. 19 cases of angina patients by double-blind, cross-test table