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32例晚期癌性疼痛患者,在常规服用麻醉剂的基础上,给予利他林治疗(早晨服10mg,中午5 mg),持续3天,对照组服安慰剂,在第4天进行交叉,第8天停止服药。按随机、对照、双盲设计研究,以评价利他林是否与麻醉剂有协同镇痛作用,能否减轻麻醉剂引起的镇静作用。28例可评价患者中,疼痛强度(按视觉疼痛范围标记为0～100mm,0=无痛,100=严重疼痛)的测定:服利他林与安慰剂者的疼痛强度分别为43±27和55±24(P<0.01);服利他林者与服安慰剂者额外加服止痛剂后,疼痛强度分别为2.2±2.4与2.9±2.9(P<0.001);服利他林与服
32 patients with advanced cancerous pain were given Ritalin (10 mg in the morning, 5 mg at noon) for 3 days on the basis of conventional anesthetic administration, placebo in the control group, crossover on the 4th day, day 8 Stop taking the medicine. A randomized, controlled, double-blind design study was conducted to evaluate whether there is a synergistic analgesic effect of Ritalin with anesthetics and whether the sedative effect of anesthetics can be alleviated. Among the 28 evaluable patients, the pain intensity (0-100 mm, 0 = no pain, 100 = severe pain, visual acuity range) was measured: the pain intensities for both the ollitin and placebo groups were 43 ± 27 and 55, respectively ± (P <0.01). The pain intensities of patients who took olidrine and placebo were 2.2 ± 2.4 and 2.9 ± 2.9, respectively (P <0.001)