论文部分内容阅读
目的:探讨中性粒细胞VCS等参数在血培养阴性的感染性心内膜炎疾病中的变化及临床意义。方法:使用BeckmanCoulter LH 750全自动血液分析仪对64例血培养阴性感染性心内膜炎患者,50例正常对照者进行常规血液分析。收集各组WBC总数及中性粒细胞VCS参数。对各组间均数进行t检验来判断差异有无统计学意义。结果:64例血培养阴性的感染性心内膜炎患者的WBC总数比正常对照组略高,差异有统计学意义(P<0.05)。中性粒细胞平均体积(MNV)和体积分布宽度(MNV-SD)均明显高于正常对照组,均差异有统计学意义(P<0.01或P<0.05)。中性粒细胞平均传导率(MNC)也高于正常对照组,差异有统计学意义(P<0.05)。但中性粒细胞平均光散射(MNS)与正常对照组比较差异无统计学意义(P>0.05)。ROC曲线显示,血培养阴性的感染性心内膜炎患者的MNV的曲线面积达到0.879,MNC的曲线面积达到0.756。在MNV≥140时,其敏感性和特异性分别为80%,82%。结论:中性粒细胞VCS参数对血培养阴性的感染性心内膜炎有较好的早期诊断提示作用。
Objective: To investigate the changes and clinical significance of neutrophil VCS and other parameters in blood culture negative infective endocarditis. Methods: Sixty-four patients with blood-borne negative infective endocarditis and 50 normal controls were subjected to routine blood analysis using a Beckman Coulter LH 750 automated hematology analyzer. Collect the total number of WBC and neutrophil VCS parameters in each group. The mean of each group t test to determine whether the difference was statistically significant. Results: The total number of WBC in 64 blood culture-negative infective endocarditis patients was slightly higher than that of the normal control group (P <0.05). The mean neutrophil volume (MNV) and volume distribution width (MNV-SD) were significantly higher than those in the normal control group (P <0.01 or P <0.05). The average neutrophil conductance (MNC) was also higher than that of the normal control group, the difference was statistically significant (P <0.05). However, the average neutrophil light scattering (MNS) compared with the normal control group was no significant difference (P> 0.05). The ROC curve showed that the MNV curve area of blood culture-negative infective endocarditis reached 0.879 and the curve area of MNC reached 0.756. At MNV ≥140, the sensitivity and specificity were 80% and 82%, respectively. CONCLUSION: The neutrophil VCS parameters have better early diagnosis and prognosis on blood culture-negative infective endocarditis.