论文部分内容阅读
实验为观察在脑一过性缺血条件下，Ｎａ＋ 通道阻断剂对海马ＣＡ１ 区锥体细胞是否具有保护作用，对９ 月龄Ｗｉｓｔａｒ大鼠进行实验。通过脑室内单独注射利多卡因、利多卡因和呋喃苯胺酸复合应用，用ＨＥ染色方法通过计算机对海马ＣＡ１ 区神经元计数。结果发现，单独注射２％ 利多卡因５μｌ，对海马ＣＡ１ 区锥体细胞无保护作用；２％ 利多卡因和２％ 呋喃苯胺酸各２５μｌ联合应用，与对照组相比，具有显著性差异（ Ｐ＜ ０．０１）。实验结果提示，Ｎａ＋ 通道阻断剂联合应用，可能是预防脑缺血引起海马ＣＡ１ 区神经细胞损伤的重要途径之一
In order to observe whether Na + channel blocker has a protective effect on hippocampal CA1 pyramidal cells under transient ischemic condition in the brain and to test 9-month-old Wistar rats. By intracerebral injection of lidocaine alone, lidocaine and furosemide acid composite application, H E staining method through the computer hippocampal CA1 neurons count. The results showed that injection of 5% 2% lidocaine alone had no protective effect on hippocampal CA1 pyramidal cells; 2% lidocaine combined with 2 5μl 2% furosemide had significant difference compared with the control group Difference (P <0.01). The experimental results suggest that the combined use of Na + channel blockers may be one of the important ways to prevent neuronal damage of hippocampal CA1 area induced by cerebral ischemia