目的比较研究ＢＡＬＢ／ｃ突变无毛小鼠与上海种小鼠皮肤特点。方法通过梭曼的离体透皮吸收、紫外线照射致皮肤损伤和组织切片方法进行这两种皮肤特点的比较。结果ＢＡＬＢ／ｃ突变无毛小鼠与上海种小鼠相比：梭曼透皮吸收量较少，皮肤耐受紫外线照射损伤能力强，皮肤屏障功能好，皮肤结构特点更接近于人。结论ＢＡＬＢ／ｃ突变无毛小鼠在皮肤病学研究中具有比上海种小鼠更为广泛的开发和应用价值。 Objective To compare the skin characteristics of BALB / c mutant hairless mice with that of Shanghai mice. Methods The skin characteristics of these two kinds of skin were compared by soman’s transdermal absorption in vitro and UV-induced skin damage and histological sectioning. Results BALB / c mutant hairless mice compared with the mice in Shanghai: soman transdermal absorption is less, the skin is resistant to ultraviolet radiation injury, skin barrier function, skin structure closer to human characteristics. Conclusions BALB / c mutant hairless mice have more extensive development and application value in dermatology than those in Shanghai.