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目的观察甲孕酮联合二联抗生素对子宫内膜炎患者细胞因子的影响。方法选取医院2015年4月-2016年10月收治的子宫内膜炎患者108例,根据入院治疗的时间顺序分为观察组和对照组,每组54例。对照组给予甲硝唑+左氧氟沙星治疗,观察组在对照组的基础给予甲孕酮治疗。比较2组患者的临床疗效、细胞因子水平及不良反应情况。结果观察组总有效率为94.44%高于对照组的77.78%,差异有统计学意义(P<0.05)。2组患者治疗前MMP-9、IL-4、IL-10及IL-2水平比较差异无统计学意义(P>0.05)。治疗后2组患者的MMP-9和IL-4水平均低于治疗前,IL-10和IL-2水平均高于治疗前,且观察组变化幅度大于对照组,差异均有统计学意义(P<0.05)。2组患者不良反应发生率差异无统计学意义(P>0.05)。结论甲孕酮联合二联抗生素治疗子宫内膜炎患者临床疗效显著且安全有效,对改善患者细胞因子水平及提升患者的生活质量具有重要意义,值得临床推广。
Objective To observe the effects of medroxyprogesterone acetate combined with antibiotics on cytokines in patients with endometritis. Methods A total of 108 patients with endometritis admitted from April 2015 to October 2016 in our hospital were divided into observation group and control group according to chronological order of admission, with 54 cases in each group. The control group was treated with metronidazole + levofloxacin, and the observation group was treated with progesterone on the basis of the control group. The clinical efficacy, cytokine levels and adverse reactions in two groups were compared. Results The total effective rate in the observation group was 94.44%, which was significantly higher than that in the control group (77.78%, P <0.05). There was no significant difference in the levels of MMP-9, IL-4, IL-10 and IL-2 between the two groups before treatment (P> 0.05). After treatment, the levels of MMP-9 and IL-4 in both groups were lower than before treatment, the levels of IL-10 and IL-2 were higher than those before treatment, and the changes in the observation group were greater than those in the control group P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusions Medroxyprogesterone acetate combined with antibiotics is effective and safe in the treatment of endometritis. It is of great significance to improve the level of cytokines in patients and improve the quality of life of patients, and is worthy of clinical promotion.