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目的 探讨非小细胞肺癌 Ki- 67的表达及其意义。方法 采用免疫组化 En Vision二步法对 46例非小细胞肺癌石蜡标本进行 Ki- 67检测 ,并结合临床病理资料作结果分析。结果 Ki- 67阳性表达率为 65.2 % (30 /46) ,与性别、年龄、肿瘤直径大小、组织学类型及分化程度无明显相关性 ,但与淋巴结转移情况密切相关 ,随着淋巴结转移程度的进展 ,其阳性率也逐渐升高 ,N2 、N3 组与 N0 组比较差异显著 (P<0 .0 5)。结论 在非小细胞肺癌中检测 Ki- 67的表达对判断和预测淋巴结转移或评估预后有一定指导意义。
Objective To investigate the expression of Ki- 67 in non-small cell lung cancer and its significance. Methods Immunohistochemical En Vision two-step method for 46 cases of non-small cell lung cancer specimens Ki- 67 detection, combined with clinical and pathological data for the analysis of the results. Results The positive expression rate of Ki- 67 was 65.2% (30/46), which was not related to gender, age, tumor diameter, histological type and differentiation degree, but closely related to the lymph node metastasis. As the degree of lymph node metastasis The positive rate of N2 and N3 groups was also significantly different from that of N0 group (P <0.05). Conclusion The detection of Ki- 67 expression in non-small cell lung cancer may be helpful in judging and predicting lymph node metastasis or assessing prognosis.