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目的：探讨硫胺素代谢异常与阿尔茨海默病（AD）大脑淀粉样蛋白沉积之间的关系。方法招募轻中度 AD 患者30例和认知功能正常的老年人112例。AD 患者接受匹茨堡化合物 B 正电子断层扫描，并计算匹茨堡化合物 B 标准摄取比值（SUVR）以定量评估患者脑内淀粉样蛋白沉积。所有研究对象测定全血硫胺素及其磷酸酯衍生物的水平，并接受简易精神状态量表（MMSE）、日常生活能力量表（ADL）及临床痴呆量表（CDR）的神经心理学评估。结果AD 患者全血硫胺素及其磷酸酯衍生物水平与皮层 SUVR 无显著相关性。AD 患者 MMSE 评分、ADL 评分及 CDR 评分与皮层 SUVR 无显著相关性。结论AD 硫胺素代谢异常和认知功能损害可能与脑内淀粉样蛋白沉积无关。“,”Objective To study the relationship between altered thiamine metabolism and cerebral amyloid deposition.Methods Thirty mild to moderate patients with AD and 1 1 2 control elderly with cognitive ability in normal range were recruited.AD patients received positron emission tomography with Pittsburgh Compound B(PET-PiB)and ratios of standard uptake value(SUVRs)were calculated to quantitatively measure cerebral amyloid deposition.All the subjects received neuropsychological examinations,including Mini Mental Status Examination(MMSE),Activity of Daily Living Scale(ADL), Clinical Dementia Rating(CDR),and the measurement of blood thiamine metabolites.Results Blood thiamine and its esters in AD were not significantly correlated with the average SUVRs in cortex.The scores of MMSE, ADL and CDR were also not correlated with the average SUVRs of cortex.Conclusion Altered thiamine metabolism and cognitive impairment in AD may be not correlated with cerebral amyloid deposition.