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目的探讨唐古特大黄地上部分水提取物急性毒性和慢性毒性试验,旨在对其毒理学安全性进行部分评价;方法按孙氏综合法进行急性毒性实验,90天喂养后以体重、食物利用率和器官病理学检测等方法进行慢性毒性试验。结果唐古特大黄地上部分提取物属于无毒级物质,初步估计最大无作用剂量102g/kg。结论唐古特大黄地上部分提取物安全的。
Objective To investigate the acute toxicity and chronic toxicity of aqueous extracts of aerial parts of Rheum tanguticum in order to evaluate their toxicological safety. Methods The acute toxicity test was carried out according to Sun’s comprehensive method. The body weight and food utilization rate after 90 days of feeding were studied. Chronic toxicity tests are performed using methods such as organ pathology tests. RESULTS: The extract of the above-ground part of Rheum tanguticum was classified as a non-toxic substance, and the maximum estimated dose was 102 g/kg. Conclusion The extracts from the aboveground part of Rheum tanguticum are safe.