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目的 研究分析原发性胃淋巴瘤(PGL)组织中腺瘤性结肠息肉病(APC)蛋白的表达,以及与临床病理特征的关系,探讨APC蛋白在PGL发生、发展中的作用及意义.方法 选取2006年6月-2011年12月中南大学湘雅医院、湖南省邵阳市中医医院PGL术后患者的临床资料和手术病理标本.采用免疫组织化学法检测45例PGL和30例胃正常黏膜组织中APC蛋白的表达.结果 PGL和胃正常黏膜组织中APC蛋白阳性表达率分别为37.78%和90.0%,差异有统计学意义(P <0.05).PGL组织中有无淋巴结转移和不同临床分期的APC蛋白阳性表达率比较,差异有统计学意义(P 0.05).结论 APC蛋白在PGL中低表达,是PGL发生的一个重要原因,提示APC蛋白可作为PGL发生的一个重要检测指标.“,”Objective?To study the expression of adenomatous polyposis coli (APC) protein in primary gastric lymphoma (PGL) tissue, and explore its relationships with clinicopathological features, as well as the role of APC protein in the development and progress of PGL.?Methods?The clinical and pathological data of 45 patients with PGL admitted in Xiangya Hospital and Shaoyang Chinese Medicine Hospital between June 2006 and December 2011 were collected. The expression of APC protein in 45 cases of PGL and 30 samples of normal gastric mucosa tissue was studied with immunohistochemical staining (SP).?Results?The positive expression rate of APC protein was 37.78% in the PGL tissues and 90.00% in the normal gastric mucosa tissue, there was a significant difference (P 0.05). The positive expression rate of APC protein was correlated with clinical stage and lymph node metastasis (P < 0.05).?Conclusions?The APC protein is lowly expressed in PGL, and it plays an important role in the tumorigenesis of PGL, and may be an important potential predictor of tumorigenesis in PGL.