目的:研究青藤碱贴剂在病理状态下的药动学规律。方法:以佐剂性关节炎大鼠为研究对象,以HPLC-UV为检测手段,测定给药以后不同时间点的血药浓度,计算药动学参数。结果:建立了专属性的血药浓度检测方法,青藤碱贴剂达峰时间约10h,MRT约24h,达峰浓度约455ng/mL,其体内行为属于一级速率、二室开放模型。结论:该方法灵敏、快速、正确、选择性强,较好的满足青藤碱的药动学研究,为合理用药提供参考。 Objective: To study the pharmacokinetics of sinomenine in the pathological state. Methods: The adjuvant arthritis rats were used as the research object. HPLC-UV was used as the detection method to determine the plasma concentration at different time points after administration, and the pharmacokinetic parameters were calculated. Results: The established method of serum concentration detection was established. The sinomenine patch peaked at about 10h, MRT was about 24h and the peak concentration was about 455ng / mL. The in vivo behavior of the sinomenine patch belongs to the first-rate and two-compartment open model. Conclusion: The method is sensitive, rapid, accurate and selective. It can meet the pharmacokinetics of sinomenine and provide reference for rational drug use.