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甲氰咪胍作为H_2受体拮抗剂,用于消化性溃疡的治疗,随着药理学研究的进展,临床应用日趋广泛,现就其在儿科的应用综述如下。 1 消化系统 1.1 轮状病毒肠炎:李氏等用甲氰咪胍治疗轮状病毒肠炎56例,按1020mg/kg·d,分3次口服或静脉滴注,以用药24～48h。大便次数≤2次/d,性状好转,水份明显减少,临床症状消失为显效;用药48～72h,大便次数≤2次/d,性状好转,水分明显减少,临床症状基本消失为有效;结果显效35.7％,有效55.3％.总有效率91.0％明显高于两个对照组。
Cimetidine as a H 2 receptor antagonist for the treatment of peptic ulcer, with the progress of pharmacological research, clinical application is more extensive, its application in pediatrics are summarized below. 1 digestive system 1.1 Rotavirus enteritis: Lee et al treated with cimetidine rotavirus enteritis in 56 cases, according to 1020mg / kg · d, 3 times orally or intravenously to medication 24 ~ 48h. Stool frequency ≤ 2 times / d, traits improved, water decreased significantly, the clinical symptoms disappeared markedly; medication 48 ~ 72h, stool frequency ≤ 2 times / d, traits improved, water significantly reduced, the clinical symptoms disappeared effectively; Results Markedly effective 35.7%, effective 55.3%. The total effective rate 91.0% was significantly higher than the two control groups.