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201022 胃泌素受体拮抗剂抑制胃癌细胞生长的可行性研究/黄广建…//中国胃肠外科杂志.-1999,2(4).-228～231 体外观察胃泌素及其受体拮抗剂丙谷胺对胃癌细胞株MKN_(45)的细胞活力、细胞内cAMP浓度及细胞凋亡的影响;并在体内观察其对胃癌细胞株MKN_(45)移植瘤的面积、重量及胃癌细胞DNA的影响。结果,在体外胃泌素能促进MKN_(45)的增殖,细胞内cAMP浓度增高,细胞凋亡百分串降低、而丙谷胺能完全阻断胃泌京的作用。体内条件下,丙谷
201022 Gastrin receptor antagonist on the feasibility of inhibiting gastric cancer cell growth / Huang Guang Jian ... / / Chinese Journal of Gastrointestinal Surgery.-1999,2 (4) .- 228 ~ 231 in vitro observation of gastrin and its receptor antagonist Prostamine on the cell viability, intracellular cAMP concentration and apoptosis of gastric cancer cell line MKN_ (45); and observe its effect on the area and weight of gastric cancer cell line MKN_ (45) influences. As a result, gastrin promoted the proliferation of MKN_ (45) in vitro, increased the intracellular cAMP concentration and decreased the apoptosis percentage, while proglumide completely blocked the effect of gastrin. In vivo conditions, Bing Valley