论文部分内容阅读
α-干扰素是慢性病毒性肝炎最有前途的治疗药物,大约可抑制30％的慢性丙型肝炎患者肝炎病毒的复制。在慢性乙型肝炎中抑制病毒复制通常伴随短暂转氨酶升高。在肝硬化患者中炎症的恶化可能导致肝代偿功能失调。作者报告慢性病毒性肝炎患者在α-干扰素治疗中或治疗后不久死于肝代偿功能失调。
Interferon-alpha is the most promising treatment for chronic viral hepatitis and inhibits hepatitis C virus replication in about 30% of patients with chronic hepatitis C. Inhibition of viral replication in chronic hepatitis B is usually accompanied by transient transaminase elevation. The worsening of inflammation in cirrhotic patients may lead to liver decompensation. The authors report that patients with chronic viral hepatitis die of hepatic compensatory dysfunction during or after IFN-α therapy.