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目的为进行乙型肝炎疫苗临床试验,了解新沂市成年人群乙型肝炎感染情况,制定该市乙肝防制策略提供依据。方法选取两个镇,调查20～60岁的成年人1480名,采用ELISA法检测血清中HBV标志物。结果新沂市成年人群HBsAg阳性率为5.27%,HBV感染率为75.68%。检出15种HBV感染模式,有16.62%人群(模式9)为乙肝疫苗临床试验目标对象。结论调查结果揭示了新沂市乙型肝炎病毒感染在成年人群中感染的流行病学特征,为疫苗临床试验和乙肝防制策略提供了背景基础资料和科学依据。
Objectives To provide evidence for hepatitis B vaccine clinical trials, understand the status of hepatitis B infection in adults in Xinyi City and formulate the strategy for prevention and control of hepatitis B in this city. Methods Two townships were selected and 1480 adults aged 20-60 years were enrolled in this study. Serum HBV markers were detected by ELISA. Results The positive rate of HBsAg in adult population in Xinyi City was 5.27% and the HBV infection rate was 75.68%. Fifteen patterns of HBV infection were detected, and 16.62% of the population (pattern 9) were targeted for clinical trials of hepatitis B vaccine. Conclusions The survey results reveal the epidemiological characteristics of hepatitis B virus infection in the adult population in Xinyi City, and provide the background basic information and scientific evidence for the clinical trials of vaccine and hepatitis B prevention and control strategy.