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本工作合成了两种性质不同的聚醚-酯多嵌段共聚物,一种是以聚对苯二甲酸乙二酯为硬链段,聚乙二醇(PEGT)为软链段的亲水性多嵌段共聚物,另一种是以聚对苯二甲酸乙二酯为硬链段,聚四亚甲基醚二醇(PTMGT)为软链段的疏水性多嵌段共聚物。将两种共聚物以一定的比例共混,制备多嵌段聚醚-酯共混物。 改变共混物的组成,研究其微相结构与血液相容性的关系。采用动态力学谱(VES)、示差扫描量热(DSC)、透射电镜(TEM)和扫描电镜(SEM)等测定共混物的微观结构,采用微球柱法评价共混物的血液相容性。实验结果表明:材料的微观非均相结构及亲水平衡是决定血液相容性的重要因素。
In this work, two kinds of polyether-ester multiblock copolymers with different properties were synthesized. One was hydrophilic polyethylene terephthalate (PEGT) with soft segment Multi-block copolymer, and the other is a hydrophobic multiblock copolymer with polyethyleneterephthalate as a hard segment and polytetramethylene ether glycol (PTMGT) as a soft segment. The two copolymers were blended in a ratio to prepare a multiblock polyether-ester blend. Changes in the composition of the blend to study the relationship between the micro-phase structure and blood compatibility. The microstructure of the blends was determined by dynamic mechanical spectroscopy (VES), differential scanning calorimetry (DSC), transmission electron microscopy (TEM) and scanning electron microscopy (SEM). The blends were evaluated for blood compatibility . The experimental results show that: the material microscopic heterogeneous structure and hydrophilic balance is an important factor in determining blood compatibility.