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以妊娠双烯醇酮醋酸酯为起始原料,经过6步反应以28.2%的总收率,合成了具有抗炎活性的海洋天然产物3β-羟基-24-降胆-5-烯-23-酸.关键反应为钯催化的烯丙基烷基化.
In this study, germacrogol acetate was used as the starting material to synthesize the 3β-hydroxy-24-nor-5-ene-23-ylamine, an anti-inflammatory natural marine product with a total yield of 28.2% Acid The key reaction is palladium catalyzed allylalkylation.