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目的了解耐甲氧西林金黄色葡萄球菌(MRSA)医院感染发生的危险因素,为采取措施预防与控制MRSA医院感染提供科学依据。方法 2005-2010年北京某三级甲等医院MRSA医院感染患者作为病例组,非医院感染患者作为对照组,通过病历信息调查相关因素,采用卡方检验及非条件logistic回归进行统计,分析MRSA医院感染的危险因素。结果单因素统计分析发现,有22项因素在病例组和对照组的分布差异有统计学意义(P≤0.05);多因素统计分析发现,入院时情况急(OR=2.17)、使用激素(OR=23.26)、机械通气(OR=96.45)、胃肠道置管(OR=3.18)、合并其他细菌感染(OR=15.66)、血红蛋白值低(值正常OR=0.43,值高OR=0.05)、使用抗菌药物类别多(1～3类OR=35.88或≥4类OR=144.29)、住院日数>3周(OR=3.95)是MRSA医院感染的危险因素。结论入院情况急、使用激素、机械通气、胃肠道置管、合并其他细菌感染、血红蛋白值低、使用抗菌药物类别多、住院日数>3周,是MRSA医院感染的危险因素,为科学预防控制MRSA提供了科学依据。
Objective To understand the risk factors of nosocomial methicillin-resistant Staphylococcus aureus (MRSA) hospital infection and provide a scientific basis for the prevention and control of MRSA nosocomial infections. Methods From 2005 to 2010, patients with MRSA hospital infection from a tertiary level Hospitals in Beijing were selected as case group and non-nosocomial infection patients as control group. The related factors were investigated by using medical record information, and were analyzed by chi-square test and non-conditional logistic regression analysis. MRSA hospital Risk factors for infection. Results According to the univariate statistical analysis, there were 22 factors in the distribution of cases and controls statistically significant difference (P≤0.05); multivariate statistical analysis found that emergency admission (OR = 2.17), the use of hormones (OR (OR = 3.26), mechanical ventilation (OR = 96.45), gastrointestinal catheterization (OR = 3.18), combined with other bacterial infections (OR = 15.66), low hemoglobin value There were more antibacterials (OR = 35.88 for category 1 to 3 or OR = 144.29 for category ≥4) and> 3 weeks for hospitalization (OR = 3.95) were risk factors for nosocomial infections in MRSA. CONCLUSIONS: Admission is urgent, the use of hormones, mechanical ventilation, gastrointestinal catheterization, combined with other bacterial infections, low value of hemoglobin, the use of antibacterial drugs more categories, hospitalization days> 3 weeks, is a risk factor for MRSA nosocomial infections for scientific prevention and control MRSA provides a scientific basis.