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目的研究NIDDM患者ApoE基因型与大、微血管病变的关系。方法采用ARMS技术检测200例NIDDM患者漱口水DNAApoE基因型。结果①∈4／3∈4／4组CAD发生率为70．8％，显著高于∈3／3组48．4％和∈2／2∈3／2组43．5％（P＜0．01或0．05）；CVD及PVD亦存在这种趋势（P＞0．05）；∈4／3∈4／4组任何证据大血管病变发生率为75％，显著高于∈3／3组51．6％和∈2／2∈3／2组47．8％（P＜0.01或0．05）。②微血管病变亦按∈2、∈3、∈4顺序递增（P＞0．05）。结论∈4等位基因增高了NIDDM患者并发血管病变，尤其是CAD的危险性。
Objective To investigate the relationship between ApoE genotypes and macrovascular microangiopathy in NIDDM patients. Methods The genotypes of DNAApoE in mouthwash of 200 patients with NIDDM were detected by ARMS. Results ① The incidence of CAD was 70.8% in ∈4 / 3 ∈4 / 4 group, which was significantly higher than that in ∈3 / 3 group (48.4%) and 43.5% of ∈2 / 2∈3 / 2 group .01 or 0.05). There was also a tendency of CVD and PVD (P> 0.05). The incidence of any macrovascular disease was 75% in ∈4 / 3ε4 / 4 group, which was significantly higher than ∈3 / 51.6% in the three groups and 47.8% in the ∈2 / 2ε3 / 2 group (P <0.01 or 0.05). ② Microvascular lesions also increased in order of ∈2, ∈3 and ∈4 (P> 0.05). Conclusion ∈ 4 allele increases the risk of vascular lesions in patients with NIDDM, especially CAD.