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目的 :为缩短单一美沙酮脱毒疗程时间 ,后期选用丁丙诺啡与洛非西定代替治疗各 5 0例作比较。方法 :海洛因依赖自愿戒毒者 1 0 0例 ,随机分为二组 ,各 5 0例 ,全部病例均先经美沙酮替代递减至末次口服 2 0 mg· d- 1以下 ,停药 2 4h以后 ,按组分别更换丁丙诺啡与洛非西定替代递减治疗 ,疗程均为 5 d。结果 :丁丙诺啡组明显优于洛非西定组 ( P<0 .0 1 )。结论 :后期改用丁丙诺啡是缩短单一美沙酮脱毒疗程 ,提高脱毒成功率的好方法。
OBJECTIVE: In order to shorten the time of single methadone detoxification treatment and compare the 50 cases treated with buprenorphine and oxymetazidine in the later period. Methods: 100 cases of heroin addicts were randomly divided into two groups of 50 cases. All cases were treated with methadone instead of decreasing to the last oral dose of 20 mg · d-1. After discontinuation of treatment for 24 hours Group were replaced by buprenorphine and losrofenacin instead of decreasing treatment, treatment were 5 d. Results: The buprenorphine group was significantly better than the losrofacid group (P <0.01). Conclusion: The late use of buprenorphine is a good way to shorten the course of single methadone detoxification and improve the success rate of detoxification.