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早在本世纪三十年代初期已经注意到慢性营养不良所引起的卵巢和附性器萎缩。随后发现投与外源垂体促性腺激素仍可使这些动物的卵巢恢复发育,表明性腺的改变并非营养不足对性腺的直接作用所致,而是通过使垂体的促性腺功能低下而
As early as the early 1930s, it has been noticed that atrophy of the ovary and the adherent caused by chronic malnutrition occurred. It was subsequently found that administration of the extraverted pituitary gonadotropin still restored the ovaries of these animals, suggesting that the gonadal changes are not caused by the direct effects of undernutrition on the gonads but by the hypogonadal pituitary gland