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目的分析隐源性肝硬化(CC)患者发生肝细胞肝癌(HCC)的危险因素。方法回顾性收集新疆医科大学第一附属医院2009年7月—2014年7月符合纳入与排除标准的CC患者241例。按照诊断结果将患者分为单纯CC组(222例)和CC合并HCC组(19例)。收集并比较患者性别、年龄、民族、体质量、是否合并高血压、是否合并糖尿病、恶性肿瘤家族史、药物过敏史、Child-Pugh评分、血红蛋白、平均红细胞体积、球蛋白、三酰甘油、总胆固醇、尿酸、肌酐、尿蛋白等指标。结果单因素条件Logistic回归分析结果显示,年龄、是否合并高血压、尿蛋白是CC患者发生HCC的影响因素(P<0.05)。多因素非条件Logistic逐步回归分析结果显示,以α=0.05为显著水准,进入回归模型的变量有年龄、合并高血压(P<0.05)。结论高血压和年龄高是CC患者发生HCC的危险因素,应对CC患者血压升高及年龄予以重视,正确评估,以降低其发生HCC的风险。
Objective To analyze the risk factors of hepatocellular carcinoma (HCC) in patients with cryptogenic cirrhosis (CC). Methods Retrospectively collected 241 cases of CC patients who met inclusion and exclusion criteria from July 2009 to July 2014 in the First Affiliated Hospital of Xinjiang Medical University. Patients were divided into simple CC group (222 cases) and CC combined HCC group (19 cases) according to the diagnosis results. Collect and compare the patient’s gender, age, nationality, body weight, hypertension, whether with diabetes, family history of malignancy, history of drug allergy, Child-Pugh score, hemoglobin, mean corpuscular volume, globulin, triglyceride, total Cholesterol, uric acid, creatinine, urinary protein and other indicators. Results The results of univariate conditional logistic regression analysis showed that age, hypertension and urinary protein were the influencing factors of HCC in patients with CC (P <0.05). The results of multivariate non-conditional Logistic stepwise regression analysis showed that the variables entered into the regression model were age and hypertension (P <0.05), with α = 0.05 as the significant level. Conclusion Hypertension and high age are risk factors for developing HCC in patients with CC, and attention should be paid to the elevation of blood pressure and age in patients with CC. Correct evaluation should be conducted to reduce the risk of developing HCC.