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作者用晚期L1210白血病小鼠, 研究了环磷酰胺血浆浓度、胃肠道吸收及其在某些组织中贮存的相互关系。小鼠在肿瘤移植后6天(中数生存期为7.7天),口服一次~(14)G标记的环磷酰胺(100毫克/公斤),对照组剂量相同。服药后5～360分钟,分批杀死实验动物,用闪烁计数仪测定样品的放射活性。作者发现白血病小鼠血浆、骨髓、肝、肺、脾和肾中~(14)G含量增高,脂肪组织中高达对照组的2～4倍。反之,在相同时间内,白血病小鼠胃肠道内~(14)G浓度比对照组显著降低。而在肿瘤移植后第4天,二组测得的结果无差异。
The authors used advanced L1210 leukemia mice to study the correlation between cyclophosphamide plasma concentrations, gastrointestinal uptake, and their storage in some tissues. Mice received a single dose of ~ (14) G-labeled cyclophosphamide (100 mg / kg) 6 days after tumor transplantation (median survival of 7.7 days) with the same dose in the control group. 5 to 360 minutes after taking the drug, the experimental animals were killed in batches and the radioactivity of the samples was measured with a scintillation counter. The authors found that leukemia mice had increased levels of ~ (14) G in plasma, bone marrow, liver, lung, spleen and kidney, up to 2-4 times higher in adipose tissue than in controls. On the contrary, the concentration of ~ (14) G in the gastrointestinal tract of leukemia mice was significantly lower than that of the control group at the same time. On the fourth day after tumor transplantation, there was no difference between the two groups.