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精胺(SP),精(?)(SPD)、尸胺(CA)、腐胺(PU)等生理性多胺,广泛存在于动植物和细菌体内,是某些氨基酸脱羧产生的一类含有两个或两个以上氨基的脂族化合物,具有一定的生理功能。1971年,Russell首次提出尿多胺含量的变化可作为诊断癌瘤和监测癌瘤的指标。此后,不少研究对体液和癌瘤组织中多胺的分析得到类似结果,陆续报道了进行多胺痕量检测的柱层析高压电泳法、薄层层析法、气液色谱/质谱法、高效液相色谱法,多胺自动分析法、自动氨基酸分析法及放射免疫法。
Physiological polyamines, such as spermine (SP), SPD, cadaverine (CA) and putrescine (PU), are widely found in animals, plants and bacteria and are a class of products produced by the decarboxylation of certain amino acids Two or more amino aliphatic compounds, have certain physiological functions. In 1971, Russell first proposed changes in urinary polyamines levels can be used as indicators of cancer diagnosis and cancer detection. Since then, many researches have obtained similar results for the analysis of polyamines in body fluids and carcinomas, and have successively reported the methods of column-based high-pressure electrophoresis, thin-layer chromatography, gas-liquid chromatography / mass spectrometry, High Performance Liquid Chromatography, Polyamine Automated Analysis, Automated Amino Acid Analysis and Radioimmunoassay.